About Sickle Cell Disease

Sickle Cell disease is the name for a group of inherited conditions that affect the red blood cells. The most serious type is called Sickle Cell Anaemia.

Sickle Cell disease mainly affects people of African, Caribbean, Middle Eastern, Eastern Mediterranean and Asian origin. In the UK, it’s particularly common in people with an African or Caribbean family background.

People with sickle cell disease produce unusually shaped red blood cells that can cause problems because they don’t live as long as healthy blood cells and they can become stuck in blood vessels.

Sickle cell disease is a serious and lifelong condition, although long-term treatment can help manage many of the problems associated with it.

People born with sickle cell disease sometimes experience problems from early childhood, although most children have few symptoms and lead normal lives most of the time.
The main symptoms of sickle cell disease are:
– painful episodes called sickle cell crises, which can be very severe and can last up to a week
– an increased risk of serious infections
– anaemia (where red blood cells can’t carry enough oxygen around the body), which can cause tiredness and shortness of breath.
Some people also experience other problems such as delayed growth, strokes and lung problems.

Sickle cell disease is caused by a faulty gene that affects how red blood cells develop.
If both parents have this faulty gene, there’s a 25% chance of each child they have being born with sickle cell disease.
The child’s parents often won’t have the condition themselves because they’re only carriers of the sickle cell trait (see below).

People with sickle cell disease will need specialist care throughout their lives.
A number of treatments are available to help manage problems caused by the condition. For example:
– painful episodes can sometimes be prevented by drinking plenty of fluids and staying warm
– pain can often be treated with ordinary painkillers such as paracetamol or ibuprofen, although sometimes treatment with stronger painkillers in hospital may be necessary
– the risk of infections can be reduced by taking daily antibiotics and ensuring you’re fully vaccinated
– a blood transfusion may be needed if severe anaemia develops
– a medicine called hydroxycarbamide (hydroxyurea) can reduce the symptoms if they’re interfering with your or your child’s life
– having regular blood transfusions (usually every 3-4 weeks) may be helpful if problems continue or get worse, or there are signs of damage caused by the condition

Stem cell or bone marrow transplants can potentially cure sickle cell disease, but they’re not done very often because of the significant risks involved.

A carrier of sickle cell is someone who carries one of the faulty genes that causes sickle cell disease, but doesn’t have the condition themselves. It’s also known as having the sickle cell trait.
People who carry sickle cell won’t develop sickle cell disease, but are at risk of having a child with the condition if their partner is also a carrier.
You can request a blood test to check if you have carry sickle cell from your GP surgery or nearest sickle cell and thalassaemia centre.

ATN has designed an exclusive range of diamante t-shirts, perfect for Sickle Cell advocates to help raise awareness about Sickle Cell Anaemia and will be donating 20% of sales from each t-shirt sold towards the care of Sickle Cell patients at the Whittington Hospital in North London. To view this range click here.

Thank you for reading and supporting.

ATN.